Study Of Urinary Calcium/Creatinine Ratio(CCR) In A Spot Sample Of Urine For Early Prediction Of Preeclampsia

Objectives: To assess the efficacy of calcium /creatinine ratio (CCR)as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. Material &Methods: Urinary calcium creatinine ratio was determined in a spot urine sample in 145 asymptomatic pregnant women between 20-28 weeks of gestation, who attended the antenatal OPD at Rama Medical hospital and Research Centre, Ghaziabad. The results were analyzed by Chi square test and t test to find the significant association of findings of preeclampsia and CCR . Area under Receiver Operator Curve (ROC) was used to find the predictive values of CCR at less than or equal to 0.04. Results: It was found that CCR had a sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of 81.2%, 96.4%, 86.6%, and 94.7% respectively with a statistical accuracy of 93.1% and p value of <0.001 (strongly significant). It was found to be a good test for prediction of preeclampsia. Conclusion: CCR at 0.04 in spot urine sample being a good test for prediction of preeclampsia can be recommended as a screening test in all asymptomatic pregnant women.